Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais, Florence; Margaritte-Jeannin, Patricia; Barnes, Kathleen C.; Cookson, William O. C.; Altmüller, Janine; Ang, Wei; Barr, R. Graham; Beaty, Terri H.; Becker, Allan B.; Beilby, John; Bisgaard, Hans; Bjornsdottir, Unnur Steina; Bleecker, Eugene; Bønnelykke, Klaus; Boomsma, Dorret I.; Bouzigon, Emmanuelle; Brightling, Christopher E.; Brossard, Myriam; Brusselle, Guy G.; Burchard, Esteban; Burkart, Kristin M.; Bush, Andrew; Chan-Yeung, Moira; Chung, Kian Fan; Couto Alves, Alexessander; Curtin, John A.; Custovic, Adnan; Daley, Denise; Jongste, Johan C.; Del-Rio-Navarro, Blanca E.; Donohue, Kathleen M.; Duijts, Liesbeth; Eng, Celeste; Eriksson, Johan G.; Farrall, Martin; Fedorova, Yuliya; Feenstra, Bjarke; Ferreira, Manuel A.; Australian Asthma Genetics, Consortium; Freidin, Maxim B.; Gajdos, Zofia; Gauderman, Jim; Gehring, Ulrike; Geller, Frank; Genuneit, Jon; Gharib, Sina A.; Gillil, Frank; Granell, Raquel; Graves, Penelope E.; Gudbjartsson, Daniel F.; Haahtela, Tari; Heckbert, Susan R.; Heederik, Dick; Heinrich, Joachim; Heliövaara, Markku; Henderson, John; Himes, Blanca E.; Hirose, Hiroshi; Hirschhorn, Joel N.; Hofman, Albert; Holt, Patrick; Hottenga, Jouke; Hudson, Thomas J.; Hui, Jennie; Imboden, Medea; Ivanov, Vladimir; Jaddoe, Vincent W. V.; James, Alan; Janson, Christer; Jarvelin, Marjo-Riitta; Jarvis, Deborah; Jones, Graham; Jonsdottir, Ingileif; Jousilahti, Pekka; Kabesch, Michael; Kähönen, Mika; Kantor, David B.; Karunas, Alexandra S.; Khusnutdinova, Elza; Koppelman, Gerard H.; Kozyrskyj, Anita L.; Kreiner, Eskil; Kubo, Michiaki; Kumar, Rajesh; Kumar, Ashish; Kuokkanen, Mikko; Lahousse, Lies; Laitinen, Tarja; Laprise, Catherine; Lathrop, Mark; Lau, Susanne; Lee, Young-Ae; Lehtimäki, Terho; Letort, Sébastien; Levin, Albert M.; Li, Guo; Liang, Liming; Loehr, Laura R.; London, Stephanie J.; Loth, Daan W.; Manichaikul, Ani; Marenholz, Ingo; Martinez, Fernando J.; Matheson, Melanie C.; Mathias, Rasika A.; Matsumoto, Kenji; Mbarek, Hamdi; McArdle, Wendy L.; Melbye, Mads; Melén, Erik; Meyers, Deborah; Michel, Sven; Mohamdi, Hamida; Musk, Arthur W.; Myers, Rachel A.; Nieuwenhuis, Maartje A. E.; Noguchi, Emiko; O’Connor, George T.; Ogorodova, Ludmila M.; Palmer, Cameron D.; Palotie, Aarno; Park, Julie E.; Pennell, Craig E.; Pershagen, Göran; Polonikov, Alexey; Postma, Dirkje S.; Probst-Hensch, Nicole; Puzyrev, Valery P.; Raby, Benjamin A.; Raitakari, Olli T.; Ramasamy, Adaikalavan; Rich, Stephen S.; Robertson, Colin F.; Romieu, Isabelle; Salam, Muhammad T.; Salomaa, Veikko; Schlünssen, Vivi; Scott, Robert; Selivanova, Polina A.; Sigsgaard, Torben; Siroux, Valérie; Simpson, Angela; Smith, Lewis J.; Solodilova, Maria; Standl, Marie; Stefansson, Kari; Strachan, David P.; Stricker, Bruno H.; Takahashi, Atsushi; Thompson, Philip J.; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiesler, Carla M. T.; Torgerson, Dara G.; Tsunoda, Tatsuhiko; Uitterlinden, André G.; van der Valk, Ralf J. P.; Vaysse, Amaury; Vedantam, Sailaja; von Berg, Andrea; von Mutius, Erika; Vonk, Judith M.; Waage, Johannes; Wareham, Nick J.; Weiss, Scott T.; White, Wendy B.; Wickman, Magnus; Widén, Elisabeth; Willemsen, Gonneke; Williams, L. Keoki; Wouters, Inge M.; Yang, James J.; Zhao, Jing Hua; Moffatt, Miriam F.; Ober, Carole; Nicolae, Dan L.

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://hdl.handle.net/20.500.12701/1741

Название:	Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Авторы:	Demenais, Florence Margaritte-Jeannin, Patricia Barnes, Kathleen C. Cookson, William O. C. Altmüller, Janine Ang, Wei Barr, R. Graham Beaty, Terri H. Becker, Allan B. Beilby, John Bisgaard, Hans Bjornsdottir, Unnur Steina Bleecker, Eugene Bønnelykke, Klaus Boomsma, Dorret I. Bouzigon, Emmanuelle Brightling, Christopher E. Brossard, Myriam Brusselle, Guy G. Burchard, Esteban Burkart, Kristin M. Bush, Andrew Chan-Yeung, Moira Chung, Kian Fan Couto Alves, Alexessander Curtin, John A. Custovic, Adnan Daley, Denise Jongste, Johan C. Del-Rio-Navarro, Blanca E. Donohue, Kathleen M. Duijts, Liesbeth Eng, Celeste Eriksson, Johan G. Farrall, Martin Fedorova, Yuliya Feenstra, Bjarke Ferreira, Manuel A. Australian Asthma Genetics, Consortium Freidin, Maxim B. Gajdos, Zofia Gauderman, Jim Gehring, Ulrike Geller, Frank Genuneit, Jon Gharib, Sina A. Gillil, Frank Granell, Raquel Graves, Penelope E. Gudbjartsson, Daniel F. Haahtela, Tari Heckbert, Susan R. Heederik, Dick Heinrich, Joachim Heliövaara, Markku Henderson, John Himes, Blanca E. Hirose, Hiroshi Hirschhorn, Joel N. Hofman, Albert Holt, Patrick Hottenga, Jouke Hudson, Thomas J. Hui, Jennie Imboden, Medea Ivanov, Vladimir Jaddoe, Vincent W. V. James, Alan Janson, Christer Jarvelin, Marjo-Riitta Jarvis, Deborah Jones, Graham Jonsdottir, Ingileif Jousilahti, Pekka Kabesch, Michael Kähönen, Mika Kantor, David B. Karunas, Alexandra S. Khusnutdinova, Elza Koppelman, Gerard H. Kozyrskyj, Anita L. Kreiner, Eskil Kubo, Michiaki Kumar, Rajesh Kumar, Ashish Kuokkanen, Mikko Lahousse, Lies Laitinen, Tarja Laprise, Catherine Lathrop, Mark Lau, Susanne Lee, Young-Ae Lehtimäki, Terho Letort, Sébastien Levin, Albert M. Li, Guo Liang, Liming Loehr, Laura R. London, Stephanie J. Loth, Daan W. Manichaikul, Ani Marenholz, Ingo Martinez, Fernando J. Matheson, Melanie C. Mathias, Rasika A. Matsumoto, Kenji Mbarek, Hamdi McArdle, Wendy L. Melbye, Mads Melén, Erik Meyers, Deborah Michel, Sven Mohamdi, Hamida Musk, Arthur W. Myers, Rachel A. Nieuwenhuis, Maartje A. E. Noguchi, Emiko O’Connor, George T. Ogorodova, Ludmila M. Palmer, Cameron D. Palotie, Aarno Park, Julie E. Pennell, Craig E. Pershagen, Göran Polonikov, Alexey Postma, Dirkje S. Probst-Hensch, Nicole Puzyrev, Valery P. Raby, Benjamin A. Raitakari, Olli T. Ramasamy, Adaikalavan Rich, Stephen S. Robertson, Colin F. Romieu, Isabelle Salam, Muhammad T. Salomaa, Veikko Schlünssen, Vivi Scott, Robert Selivanova, Polina A. Sigsgaard, Torben Siroux, Valérie Simpson, Angela Smith, Lewis J. Solodilova, Maria Standl, Marie Stefansson, Kari Strachan, David P. Stricker, Bruno H. Takahashi, Atsushi Thompson, Philip J. Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tiesler, Carla M. T. Torgerson, Dara G. Tsunoda, Tatsuhiko Uitterlinden, André G. van der Valk, Ralf J. P. Vaysse, Amaury Vedantam, Sailaja von Berg, Andrea von Mutius, Erika Vonk, Judith M. Waage, Johannes Wareham, Nick J. Weiss, Scott T. White, Wendy B. Wickman, Magnus Widén, Elisabeth Willemsen, Gonneke Williams, L. Keoki Wouters, Inge M. Yang, James J. Zhao, Jing Hua Moffatt, Miriam F. Ober, Carole Nicolae, Dan L.
Ключевые слова:	Asthma Genome-wide association studies
Дата публикации:	22-дек-2017
Издательство:	Springer Nature
Серия/номер:	Nature Genetics;Volume 50
Краткий осмотр (реферат):	We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
URI (Унифицированный идентификатор ресурса):	https://doi.org/10.1038/s41588-017-0014-7 http://hdl.handle.net/20.500.12701/1741
Располагается в коллекциях:	Nature Genetics

Файлы этого ресурса:

Файл	Описание	Размер	Формат
10.1038_s41588-017-0014-7.pdf		2 MB	Adobe PDF	Просмотреть/Открыть

Показать полное описание ресурса Просмотр статистики

Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.