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dc.contributor.authorDemenais, Florence-
dc.contributor.authorMargaritte-Jeannin, Patricia-
dc.contributor.authorBarnes, Kathleen C.-
dc.contributor.authorCookson, William O. C.-
dc.contributor.authorAltmüller, Janine-
dc.contributor.authorAng, Wei-
dc.contributor.authorBarr, R. Graham-
dc.contributor.authorBeaty, Terri H.-
dc.contributor.authorBecker, Allan B.-
dc.contributor.authorBeilby, John-
dc.contributor.authorBisgaard, Hans-
dc.contributor.authorBjornsdottir, Unnur Steina-
dc.contributor.authorBleecker, Eugene-
dc.contributor.authorBønnelykke, Klaus-
dc.contributor.authorBoomsma, Dorret I.-
dc.contributor.authorBouzigon, Emmanuelle-
dc.contributor.authorBrightling, Christopher E.-
dc.contributor.authorBrossard, Myriam-
dc.contributor.authorBrusselle, Guy G.-
dc.contributor.authorBurchard, Esteban-
dc.contributor.authorBurkart, Kristin M.-
dc.contributor.authorBush, Andrew-
dc.contributor.authorChan-Yeung, Moira-
dc.contributor.authorChung, Kian Fan-
dc.contributor.authorCouto Alves, Alexessander-
dc.contributor.authorCurtin, John A.-
dc.contributor.authorCustovic, Adnan-
dc.contributor.authorDaley, Denise-
dc.contributor.authorJongste, Johan C.-
dc.contributor.authorDel-Rio-Navarro, Blanca E.-
dc.contributor.authorDonohue, Kathleen M.-
dc.contributor.authorDuijts, Liesbeth-
dc.contributor.authorEng, Celeste-
dc.contributor.authorEriksson, Johan G.-
dc.contributor.authorFarrall, Martin-
dc.contributor.authorFedorova, Yuliya-
dc.contributor.authorFeenstra, Bjarke-
dc.contributor.authorFerreira, Manuel A.-
dc.contributor.authorAustralian Asthma Genetics, Consortium-
dc.contributor.authorFreidin, Maxim B.-
dc.contributor.authorGajdos, Zofia-
dc.contributor.authorGauderman, Jim-
dc.contributor.authorGehring, Ulrike-
dc.contributor.authorGeller, Frank-
dc.contributor.authorGenuneit, Jon-
dc.contributor.authorGharib, Sina A.-
dc.contributor.authorGillil, Frank-
dc.contributor.authorGranell, Raquel-
dc.contributor.authorGraves, Penelope E.-
dc.contributor.authorGudbjartsson, Daniel F.-
dc.contributor.authorHaahtela, Tari-
dc.contributor.authorHeckbert, Susan R.-
dc.contributor.authorHeederik, Dick-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorHeliövaara, Markku-
dc.contributor.authorHenderson, John-
dc.contributor.authorHimes, Blanca E.-
dc.contributor.authorHirose, Hiroshi-
dc.contributor.authorHirschhorn, Joel N.-
dc.contributor.authorHofman, Albert-
dc.contributor.authorHolt, Patrick-
dc.contributor.authorHottenga, Jouke-
dc.contributor.authorHudson, Thomas J.-
dc.contributor.authorHui, Jennie-
dc.contributor.authorImboden, Medea-
dc.contributor.authorIvanov, Vladimir-
dc.contributor.authorJaddoe, Vincent W. V.-
dc.contributor.authorJames, Alan-
dc.contributor.authorJanson, Christer-
dc.contributor.authorJarvelin, Marjo-Riitta-
dc.contributor.authorJarvis, Deborah-
dc.contributor.authorJones, Graham-
dc.contributor.authorJonsdottir, Ingileif-
dc.contributor.authorJousilahti, Pekka-
dc.contributor.authorKabesch, Michael-
dc.contributor.authorKähönen, Mika-
dc.contributor.authorKantor, David B.-
dc.contributor.authorKarunas, Alexandra S.-
dc.contributor.authorKhusnutdinova, Elza-
dc.contributor.authorKoppelman, Gerard H.-
dc.contributor.authorKozyrskyj, Anita L.-
dc.contributor.authorKreiner, Eskil-
dc.contributor.authorKubo, Michiaki-
dc.contributor.authorKumar, Rajesh-
dc.contributor.authorKumar, Ashish-
dc.contributor.authorKuokkanen, Mikko-
dc.contributor.authorLahousse, Lies-
dc.contributor.authorLaitinen, Tarja-
dc.contributor.authorLaprise, Catherine-
dc.contributor.authorLathrop, Mark-
dc.contributor.authorLau, Susanne-
dc.contributor.authorLee, Young-Ae-
dc.contributor.authorLehtimäki, Terho-
dc.contributor.authorLetort, Sébastien-
dc.contributor.authorLevin, Albert M.-
dc.contributor.authorLi, Guo-
dc.contributor.authorLiang, Liming-
dc.contributor.authorLoehr, Laura R.-
dc.contributor.authorLondon, Stephanie J.-
dc.contributor.authorLoth, Daan W.-
dc.contributor.authorManichaikul, Ani-
dc.contributor.authorMarenholz, Ingo-
dc.contributor.authorMartinez, Fernando J.-
dc.contributor.authorMatheson, Melanie C.-
dc.contributor.authorMathias, Rasika A.-
dc.contributor.authorMatsumoto, Kenji-
dc.contributor.authorMbarek, Hamdi-
dc.contributor.authorMcArdle, Wendy L.-
dc.contributor.authorMelbye, Mads-
dc.contributor.authorMelén, Erik-
dc.contributor.authorMeyers, Deborah-
dc.contributor.authorMichel, Sven-
dc.contributor.authorMohamdi, Hamida-
dc.contributor.authorMusk, Arthur W.-
dc.contributor.authorMyers, Rachel A.-
dc.contributor.authorNieuwenhuis, Maartje A. E.-
dc.contributor.authorNoguchi, Emiko-
dc.contributor.authorO’Connor, George T.-
dc.contributor.authorOgorodova, Ludmila M.-
dc.contributor.authorPalmer, Cameron D.-
dc.contributor.authorPalotie, Aarno-
dc.contributor.authorPark, Julie E.-
dc.contributor.authorPennell, Craig E.-
dc.contributor.authorPershagen, Göran-
dc.contributor.authorPolonikov, Alexey-
dc.contributor.authorPostma, Dirkje S.-
dc.contributor.authorProbst-Hensch, Nicole-
dc.contributor.authorPuzyrev, Valery P.-
dc.contributor.authorRaby, Benjamin A.-
dc.contributor.authorRaitakari, Olli T.-
dc.contributor.authorRamasamy, Adaikalavan-
dc.contributor.authorRich, Stephen S.-
dc.contributor.authorRobertson, Colin F.-
dc.contributor.authorRomieu, Isabelle-
dc.contributor.authorSalam, Muhammad T.-
dc.contributor.authorSalomaa, Veikko-
dc.contributor.authorSchlünssen, Vivi-
dc.contributor.authorScott, Robert-
dc.contributor.authorSelivanova, Polina A.-
dc.contributor.authorSigsgaard, Torben-
dc.contributor.authorSiroux, Valérie-
dc.contributor.authorSimpson, Angela-
dc.contributor.authorSmith, Lewis J.-
dc.contributor.authorSolodilova, Maria-
dc.contributor.authorStandl, Marie-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorStrachan, David P.-
dc.contributor.authorStricker, Bruno H.-
dc.contributor.authorTakahashi, Atsushi-
dc.contributor.authorThompson, Philip J.-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorTiesler, Carla M. T.-
dc.contributor.authorTorgerson, Dara G.-
dc.contributor.authorTsunoda, Tatsuhiko-
dc.contributor.authorUitterlinden, André G.-
dc.contributor.authorvan der Valk, Ralf J. P.-
dc.contributor.authorVaysse, Amaury-
dc.contributor.authorVedantam, Sailaja-
dc.contributor.authorvon Berg, Andrea-
dc.contributor.authorvon Mutius, Erika-
dc.contributor.authorVonk, Judith M.-
dc.contributor.authorWaage, Johannes-
dc.contributor.authorWareham, Nick J.-
dc.contributor.authorWeiss, Scott T.-
dc.contributor.authorWhite, Wendy B.-
dc.contributor.authorWickman, Magnus-
dc.contributor.authorWidén, Elisabeth-
dc.contributor.authorWillemsen, Gonneke-
dc.contributor.authorWilliams, L. Keoki-
dc.contributor.authorWouters, Inge M.-
dc.contributor.authorYang, James J.-
dc.contributor.authorZhao, Jing Hua-
dc.contributor.authorMoffatt, Miriam F.-
dc.contributor.authorOber, Carole-
dc.contributor.authorNicolae, Dan L.-
dc.date.accessioned2022-03-29T05:46:48Z-
dc.date.available2022-03-29T05:46:48Z-
dc.date.issued2017-12-22-
dc.identifier.urihttps://doi.org/10.1038/s41588-017-0014-7-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1741-
dc.description.abstractWe examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.ru_RU
dc.language.isoenru_RU
dc.publisherSpringer Natureru_RU
dc.relation.ispartofseriesNature Genetics;Volume 50-
dc.subjectAsthmaru_RU
dc.subjectGenome-wide association studiesru_RU
dc.titleMultiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marksru_RU
dc.typeArticleru_RU
Располагается в коллекциях:Nature Genetics

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