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dc.contributor.authorRoschina, Olga V.-
dc.contributor.authorLevchuk, Lyudmila A.-
dc.contributor.authorBoiko, Anastasiia S.-
dc.contributor.authorMichalitskaya, Ekaterina V.-
dc.contributor.authorEpimakhova, Elena V.-
dc.contributor.authorLosenkov, Innokentiy S.-
dc.contributor.authorSimutkin, German G.-
dc.contributor.authorLoonen, Anton J. M.-
dc.contributor.authorBokhan, Nikolay A.-
dc.contributor.authorIvanova, Svetlana A.-
dc.date.accessioned2022-06-24T11:37:46Z-
dc.date.available2022-06-24T11:37:46Z-
dc.date.issued2021-12-03-
dc.identifier.urihttps://doi.org/10.3390/jcm10235696-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/2141-
dc.description.abstractBackground: The neuropeptides β-endorphin and oxytocin are released into the bloodstream as hormones from the pituitary gland but also have an important function as neuroregulators in the forebrain. The blood levels of both polypeptides have been shown to reflect depressive symptoms. β-Endorphin, in particular, is also involved in abstinence from alcohol. Methods: The serum levels of β-endorphin and oxytocin were measured during the early withdrawal phase in patients with alcohol use disorder (AUD) with (N = 35) or without (N = 45) depressive comorbidity and compared with those in healthy volunteers (N = 23). In addition to comparing the groups, the study examined whether serum levels correlated with various psychometric measures of dependence, depression and aggression, as well as with clinical characteristics of dependence. Results: Both serum levels of beta-endorphin and oxytocin were significantly lower in patients than those in healthy controls (p = 0.011 for β-endorphin and p = 0.005 for oxytocin, Kruskal–Wallis test). In patients with depressive comorbidity, the significance was greatest (p = 0.005 for β-endorphin and p = 0.004 for oxytocin, U-test). There was no correlation with clinical or psychometric parameters (p > 0.05, Spearman test), but beta-endorphin levels did correlate significantly with physical aggression (p = 0.026, Spearman test). Conclusions: Serum levels of β-endorphin and oxytocin are lower in patients with AUD, particularly in those with depressive comorbidity. β-Endorphin levels correlated with physical aggression according to the Buss–Durkee (BDHI) estimates.ru_RU
dc.language.isoenru_RU
dc.publisherMDPIru_RU
dc.relation.ispartofseriesJournal of Clinical Medicine;Volume 10, Issue 23-
dc.subjectβ-endorphinru_RU
dc.subjectoxytocinru_RU
dc.subjectbloodru_RU
dc.subjectalcohol use disorderru_RU
dc.subjectaddiction-related mood changeru_RU
dc.subjectaggressive behaviorru_RU
dc.titleBeta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depressionru_RU
dc.typeArticleru_RU
Располагается в коллекциях:Journal of Clinical Medicine

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