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dc.contributor.authorGridina, M.M.-
dc.contributor.authorNikitina, T.V.-
dc.contributor.authorOrlova, P.A.-
dc.contributor.authorMinina, J.M.-
dc.contributor.authorKashevarova, A.A.-
dc.contributor.authorYakovleva, Yu.S.-
dc.contributor.authorLopatkina, M.E.-
dc.contributor.authorVasilyev, S.A.-
dc.contributor.authorFedotov, D.A.-
dc.contributor.authorMikhailik, L.I.-
dc.contributor.authorNazarenko, L.P.-
dc.contributor.authorLebedev, I.N.-
dc.contributor.authorSerova, O.L.-
dc.date.accessioned2022-04-08T08:13:59Z-
dc.date.available2022-04-08T08:13:59Z-
dc.date.issued2020-10-20-
dc.identifier.urihttps://doi.org/10.1016/j.scr.2020.102024-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1880-
dc.description.abstractRing chromosomes are structural aberrations commonly associated with disease phenotype. We consider necessary to create the iPSCs with a ring chromosome 8, which can be used for disease modeling and related research. The ICGi025-A iPSCs line was obtained by the reprogramming of the skin fibroblasts from a 1-year-old boy with 46,XY,r(8)/45,XY,–8 mosaicism, developmental delay, microcephaly, dysmorphic features, diffuse muscle hypotonia, moderate proximal muscle weakness, feeding problems, and motor alalia. The iPSCs had expression of the pluripotency-associated markers. In vitro differentiated cells expressed the markers of the cells of three germ layers. That data allowed us to conclude that ICGi025-A cells were pluripotent.ru_RU
dc.language.isoenru_RU
dc.publisherElsevier B.V.ru_RU
dc.relation.ispartofseriesStem Cell Research;Volume 49-
dc.titleEstablishment of an induced pluripotent stem cell line (ICGi025-A) from fibroblasts of a patient with 46,XY,r(8)/45,XY,–8 mosaicismru_RU
dc.typeArticleru_RU
Располагается в коллекциях:Stem Cell Research

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