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dc.contributor.authorIvanova, S. A.-
dc.contributor.authorLoonen, A. J. M.-
dc.contributor.authorPechlivanoglou, P.-
dc.contributor.authorFreidin, M. B.-
dc.contributor.authorAl Hadithy, A. F. Y.-
dc.contributor.authorRudikov, E. V.-
dc.contributor.authorZhukova, I. A.-
dc.contributor.authorGovorin, N. V.-
dc.contributor.authorSorokina, V. A.-
dc.contributor.authorFedorenko, O. Y.-
dc.contributor.authorAlifirova, V. M.-
dc.contributor.authorSemke, A. V.-
dc.contributor.authorBrouwers, J. R. B. J.-
dc.contributor.authorWilffert, B.-
dc.date.accessioned2022-04-05T06:05:52Z-
dc.date.available2022-04-05T06:05:52Z-
dc.date.issued2012-01-10-
dc.identifier.urihttps://doi.org/10.1038/tp.2011.66-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1841-
dc.description.abstractDyskinesias are involuntary muscle movements that occur spontaneously in Huntington's disease (HD) and after long-term treatments for Parkinson's disease (levodopa-induced dyskinesia; LID) or for schizophrenia (tardive dyskinesia, TD). Previous studies suggested that dyskinesias in these three conditions originate from different neuronal pathways that converge on overstimulation of the motor cortex. We hypothesized that the same variants of the N-methyl-D-aspartate receptor gene that were previously associated with the age of dyskinesia onset in HD were also associated with the vulnerability for TD and not LID. Genotyping patients with LID and TD revealed, however, that these two variants were dose-dependently associated with susceptibility to LID, but not TD. This suggested that LID, TD and HD might arise from the same neuronal pathways, but TD results from a different mechanism.ru_RU
dc.language.isoenru_RU
dc.publisherSpringer Natureru_RU
dc.relation.ispartofseriesTranslational Psychiatry;Volume 2-
dc.subjectextra-pyramidalru_RU
dc.subjectGRIN2Aru_RU
dc.subjectlevodopa-induced dyskinesiaru_RU
dc.subjectmedium spiny neuronru_RU
dc.subjectNMDAru_RU
dc.subjecttardive dyskinesiaru_RU
dc.titleNMDA receptor genotypes associated with the vulnerability to develop dyskinesiaru_RU
dc.typeArticleru_RU
Располагается в коллекциях:Translational Psychiatry

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