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dc.contributor.authorGruzdeva, Olga-
dc.contributor.authorUchasova, Evgenya-
dc.contributor.authorDyleva, Yulia-
dc.contributor.authorBorodkina, Daria-
dc.contributor.authorAkbasheva, Olga-
dc.contributor.authorBelik, Ekaterina-
dc.contributor.authorKaretnikova, Viktoria-
dc.contributor.authorBrel, Natalia-
dc.contributor.authorKokov, Alexander-
dc.contributor.authorKashtalap, Vasiliy-
dc.contributor.authorBarbarash, Olga-
dc.date.accessioned2022-03-28T07:58:00Z-
dc.date.available2022-03-28T07:58:00Z-
dc.date.issued2018-03-16-
dc.identifier.urihttps://doi.org/10.1186/s12933-018-0679-y-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1737-
dc.description.abstractBackground Determination of the impact of visceral obesity and epicardial adipose tissue thickness on stimulating growth factor levels during hospitalization for myocardial infarction is of potential importance for predicting outcomes and assessing the development of cardiofibrotic changes associated with maladaptive myocardial remodeling. In this study, we aimed to investigate the relationships between epicardial adipose tissue thickness, adipokine profiles, and the stimulating growth factor 2/interleukin-33 signaling system during hospitalization for myocardial infarction, and with the cardiac fibrosis extent 1-year post-MI in patients with visceral obesity. Methods Eighty-eight patients with myocardial infarction were grouped based on their visceral obesity. Serum leptin, adiponectin, stimulating growth factor 2, and interleukin-33 levels were measured on days 1 and 12 and at 1 year. The epicardial adipose tissue widths and the cardiac fibrosis areas were measured on day 12 and at 1 year. Results Visceral obesity was associated with epicardial adipose tissue thickness increases, adipokine imbalances, elevated leptin levels, and lower adiponectin levels during early hospitalization, and cardiac fibrosis development. Patients without visceral obesity had higher interleukin-33 and stimulating growth factor 2 levels during early hospitalization and lower cardiac fibrosis rates. Epicardial adipose tissue thickness was positively associated with cardiac fibrosis prevalence and interleukin-33 levels and negatively associated with stimulating growth factor 2 levels. The cardiac fibrosis extent was negatively associated with interleukin-33 levels and positively associated with stimulating growth factor 2 levels. Conclusions Increases in epicardial adipose tissue thickness are associated with cardiac fibrosis development 1-year post-myocardial infarction and are higher in patients with visceral obesity. The metabolic activity of the epicardial adipose tissue is associated with elevated interleukin-33 and reduced stimulating growth factor 2 levels.ru_RU
dc.language.isoenru_RU
dc.publisherBMCru_RU
dc.relation.ispartofseriesCardiovascular Diabetology;Volume 17-
dc.subjectVisceral obesityru_RU
dc.subjectEpicardial adipose tissueru_RU
dc.subjectCardiac fibrosisru_RU
dc.subjectAdiponectinru_RU
dc.subjectStimulating growth factor 2ru_RU
dc.subjectInterleukin-33ru_RU
dc.titleRelationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarctionru_RU
dc.typeArticleru_RU
Располагается в коллекциях:Cardiovascular Diabetology

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