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http://hdl.handle.net/20.500.12701/1722
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Mukhamadiyarov, Rinat A. | - |
dc.contributor.author | Senokosova, Evgeniya A. | - |
dc.contributor.author | Krutitsky, Sergey S. | - |
dc.contributor.author | Voevoda, Darya V. | - |
dc.contributor.author | Pyshnaya, Inna A. | - |
dc.contributor.author | Ivanov, Vladimir V. | - |
dc.contributor.author | Lewis, Martin J. | - |
dc.contributor.author | Khaliulin, Igor | - |
dc.date.accessioned | 2022-03-24T09:39:53Z | - |
dc.date.available | 2022-03-24T09:39:53Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.uri | https://doi.org/10.1097/FJC.0000000000000606 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12701/1722 | - |
dc.description.abstract | Liposomes have the potential to be used for drug delivery. Meanwhile, liposome size may affect their accumulation in the target tissue. We investigated the myocardial accumulation of 2 populations of liposomes (∼70 and 110 nm diameter) during ischemia and their effect on ischemia/reperfusion injury. Isolated rat hearts were subjected to 30 minutes of low-flow ischemia with the liposomes, followed by 30 minutes of liposome-free reperfusion. The liposomes were loaded with the fluorescent dye Nile Red to assess their accumulation in the myocardium. The cardiac functional recovery during reperfusion was evaluated using force–velocity characteristics and coronary flow (CF). Reperfusion injury was evaluated by lactate dehydrogenase release. In addition, CF and contractility were assessed in hearts perfused normally with 70 nm liposomes. There was a 6- and 4-fold greater accumulation of the small liposomes in the myocardium and mitochondria, respectively, compared with the large liposomes. Importantly, even without any incorporated drugs, both populations of liposomes improved functional recovery and reduced lactate dehydrogenase release. However, the smaller liposomes showed significantly higher protective and vasodilatory effects during reperfusion than the larger particles. These liposomes also increased CF and contractility during normal perfusion. We suggest that the protective properties of the liposomes could be related to their membrane-stabilizing effect. | ru_RU |
dc.language.iso | en | ru_RU |
dc.publisher | Wolters Kluwer Health | ru_RU |
dc.relation.ispartofseries | Journal of Cardiovascular Pharmacology;Volume 72, Issue 3 | - |
dc.subject | drug delivery | ru_RU |
dc.subject | heart | ru_RU |
dc.subject | size of liposomes | ru_RU |
dc.subject | myocardial accumulation and distribution | ru_RU |
dc.subject | cardiac ischemia/reperfusion injury | ru_RU |
dc.subject | cardioprotection | ru_RU |
dc.title | Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart | ru_RU |
dc.type | Article | ru_RU |
Располагается в коллекциях: | Journal of Cardiovascular Pharmacology |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.1097_FJC.0000000000000606.pdf.pdf | 730,53 kB | Adobe PDF | Просмотреть/Открыть |
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