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dc.contributor.authorGruzdeva, Olga-
dc.contributor.authorDyleva, Yulia-
dc.contributor.authorUchasova, Evgenya-
dc.contributor.authorAkbasheva, Olga-
dc.contributor.authorKaretnikova, Victoria-
dc.contributor.authorKashtalap, Vasiliy-
dc.contributor.authorShilov, Aleksandr-
dc.contributor.authorPolikutina, Olga-
dc.contributor.authorSlepynina, Yulia-
dc.contributor.authorBarbarash, Olga-
dc.date.accessioned2022-03-21T08:14:23Z-
dc.date.available2022-03-21T08:14:23Z-
dc.date.issued2019-06-10-
dc.identifier.urihttps://doi.org/10.18632/aging.101994-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1700-
dc.description.abstractAim: To assess growth stimulating factor ST2 and N-terminal pro b-type natriuretic peptide (NT-proBNP) levels in the sera of myocardial infraction (MI) patients, and their correlation with the adaptive and maladaptive variants of cardiac remodelling. Methods: 87 patients (65 male, 22 females; 67±8.36 years) with ST-elevated MI were included in this study, and 67 patients had an adaptive, physiological, while 20 patients had a maladaptive, pathological variant of myocardium remodelling. Results: On day 1, ST2 and NT-proBNP levels were shown to increase 2.4 and 4.5 folds, respectively, compared with those in the control. ST2 levels in patients with maladaptive remodelling were 1.5-fold higher than those in the adaptive remodelling group. On day 12, a decrease in ST2 levels was observed in both groups. NT-proBNP levels increased 1.8 folds in both groups on day 1, compared with those in the controls. Increased ST2 levels on day 1 after MI were shown to increase the risk of maladaptive remodelling 4.5 folds, while high NT-proBNP levels increased this risk 2.3 times. Conclusions: ST2 level determination allows us to predict the risk of maladaptive remodelling with a higher sensitivity and specificity than using NT-proBNP levels.ru_RU
dc.language.isoenru_RU
dc.publisherImpact Journals, LLCru_RU
dc.relation.ispartofseriesAging;Volume 11, Issue 11-
dc.subjectpostinfarction remodellingru_RU
dc.subjectgrowth stimulating factor ST2ru_RU
dc.subjectNT-proBNPru_RU
dc.subjectmyocardial infractionru_RU
dc.titleBiological markers and cardiac remodelling following the myocardial infarctionru_RU
dc.typeArticleru_RU
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