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dc.contributor.authorKhlusov, Igor-
dc.contributor.authorAvdeeva, Elena-
dc.contributor.authorShupletsova, Valeria-
dc.contributor.authorKhaziakhmatova, Olga-
dc.contributor.authorLitvinova, Larisa-
dc.contributor.authorPorokhova, Ekaterina-
dc.contributor.authorReshetov, Yaroslav-
dc.contributor.authorZvereva, Irina-
dc.contributor.authorMushtovatova, Lyudmila-
dc.contributor.authorKarpova, Mariia-
dc.contributor.authorGuryev, Artem-
dc.contributor.authorSukhodolo, Irina-
dc.contributor.authorBelousov, Mikhail-
dc.date.accessioned2022-03-04T09:45:41Z-
dc.date.available2022-03-04T09:45:41Z-
dc.date.issued2019-10-12-
dc.identifier.urihttps://doi.org/10.3390/molecules24203680-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1643-
dc.description.abstractThe osteogenic, cytotoxic, and antibacterial activities of polysaccharide (PS-SC) and flavonoid (F-SC) fractions isolated from the leaves extract of Saussurea controversa were studied in vitro. F-SC consists of the five quercetin glycosides in the ratio 2:8:10:1:4, which were isolated from the leaves extract of S. controversa and have been characterized previously. PS-SC was first isolated from the leaves extract of S. controversa and has been described. PS-SC consists in 30 compounds is characterized by a high degree of heterogeneity with a heterogeneity index of 19.74. The Mw and Mn of PS-SC were 108.6 and 5.5 kDa, respectively. Structural fragments are represented by galactose, arabinose, xylose, glucose, uronic acids, mannose, and rhamnose in a 10.1:3.3:2.2:2.1:1.7:0.9:0.5 molar ratio. F-SC as compared with PS-SC showed in vitro microbicidal (50 g/L) and better bacteriostatic (6.25 g/L versus 25 g/L of PS-SC) effects against the 24-h growth of Staphylococcus aureus strain 209 P and a 21-day absence of cytotoxicity on human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs). Both fractions (PS-SC > F-SC) at doses of 10–50 mg/L stimulated differentiation of hAMMSCs into secreting osteoblasts accompanied by local mineralization of extracellular matrix. These fractions of S. controversa and especially F-SC, might be promising peroral drugs in the complex treatment of bone fractures and for prophylaxis of their infectious complications.ru_RU
dc.language.isoenru_RU
dc.publisherMDPIru_RU
dc.relation.ispartofseriesMolecules;Volume 24, Issue 20-
dc.subjectSaussurea controversa DC (Asteraceae)ru_RU
dc.subjectpolysaccharidesru_RU
dc.subjectflavonoidsru_RU
dc.subjecthuman adipose-derived multipotent mesenchymal stromal cellsru_RU
dc.subjectcytotoxicityru_RU
dc.subjectalizarin red stainingru_RU
dc.subjectStaphylococcus aureus growthru_RU
dc.titleComparative In Vitro Evaluation of Antibacterial and Osteogenic Activity of Polysaccharide and Flavonoid Fractions Isolated from the leaves of Saussurea controversaru_RU
dc.typeArticleru_RU
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